A recent study suggests that individuals who stop using blockbuster weight-loss injections like semaglutide or tirzepatide can put back on lost weight at a significantly accelerated pace than those who halt conventional diet and exercise plans.
Research printed in a major health publication points out that while obese individuals can lose about a fifth of their total mass while on the medication, the mass comes back at an estimated rate of 0.8 kg per month once they quit.
"Users using these drugs should be aware of the risk of rapid weight regain when the therapy concludes," cautioned expert Dr. Susan Jebb.
Such speed of regain means a reversion to original weight within about one and a half years.
Analyzing Treatments
The analysis, which looked at 37 of trials involving thousands of participants, contrasted the outcomes of the injectable medications with conventional dieting.
Scientists note that individuals who lose weight through diet and exercise typically have a more gradual creep back—perhaps 0.1 kg a month—once they finish.
Explaining the Fast Rebound
Experts believe the mode of action of the jabs accounts for the accelerated rebound.
These medications copy a body's own chemical called GLP-1, which helps regulate feelings of fullness.
"Long-term administration of GLP-1 concentrations far above than normal might result in the body to generate a reduced amount of its endogenous GLP-1, and could reduce responsiveness to its effects," noted Dr. Adam Collins, a nutrition researcher.
"Stopping of this GLP-1 'fix' leads to appetite is uncontrolled, making overeating a significant risk."
A Chronic Issue?
Health authorities advise the jabs for people with weight-linked health risks, alongside recommended lifestyle changes.
Many experts say that, due to the significant potential of relapse, the treatment should be considered ongoing.
This opinion is echoed by drug manufacturers, who say that the results "underscore the long-term character of excess weight," akin to managing conditions like high blood pressure.
User Accounts
People who have come off the medication describe a intense resurgence of hunger.
"It felt as if a trigger activating and you're instantly extremely hungry," said a patient.
This difficulty is compounded if individuals have not adopted permanent dietary or behavioural changes during therapy.
Growing Use
Recent estimates suggest that a significant number of adults in the UK have tried these injections in the last 12 months, with desire being substantial.
- Adoption is more common among women compared to men.
- The 40s and 50s demographic shows the highest usage rates.
- A large proportion access the drugs through private prescriptions rather than public health services.
Ultimately, clinicians caution that while these medications are effective tools for weight loss, they are not a standalone solution and lasting health benefits relies on combined behavioural changes.
